Creative Biolabs Supports Ribosome Discovery with Superlative Analysis Services
(YorkPedia Editorial):- New York City, New York Jan 18, 2023 (Issuewire.com) – Ribosomes, the site of protein synthesis in the cell, are vital for cell growth and survival. In the last few decades, a number of diseases have been discovered to be related to ribosomes. Understanding their great potential in the research on disease treatment, Creative Biolabs has unveiled a series of CRO services, highlighting ribosome analysis services.
With industry-leading expertise in ribosome research, Creative Biolabs has established a complete experimental platform for ribosome purification and analysis. The custom analysis services cover ribosomal transcriptome and ribosomal proteomics.
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The scientist team believes that to understand ribosome translation and regulation, it is essential to determine the location and number of ribosomes on mRNA in vivo, thus is dedicated to assembling a one-stop ribosomal transcriptome analysis service, including but not limited to
- Ribosome Profiling: Preparation of physiological samples, nuclease digestion to remove unbound fragments, ribosome-protected fragment purification, library construction, deep sequencing, and computational analysis.
- Polysome Profiling: Preparation of cell lysates and sucrose gradients, isolation of polysomes, RNA isolation and RT-qPCR MQ, protein isolation, and SDS-PAGE.
- Ribosome Complex Profiling: Global translation initiation sequencing (GTI-Seq) technology to cover the whole profiling process.
- Ribosome RNA Sequencing: Digest free mRNA with nucleases, and enrich them for ribosome-mRNA complexes to obtain the target RNA fragment, library construction, and data analysis.
Considering ribosomal proteomics a powerful tool to understand the translation mechanism of ribosomes, Creative Biolabs now provides customized ribosomal proteomics services based on the standard process.
- Ribosomal Proteome Identification: Label-dependent strategies (SILAC, iTRAQ, ICAT, etc.) and label-independent strategies (coupling RFHR 2-DE with MALDI-TOF MS and MRM).
- Ribosomal Protein Expression and Analysis: Plasmid construction, gene expression, protein purification, protein expression, ribosome-interacting proteins analysis, etc.
The expert team ensures a vast variety of data and initiatives around clients’ ribosome solutions, covering translational control and measure gene expression, translation start sites, the rate of protein synthesis, and the prediction of protein abundance, which will help clients make informed decisions and set the right groundwork to succeed.
Detailed information can be found at the official website https://ribosome.creative-biolabs.com/.
About Creative Biolabs
Equipped with cutting-edge instruments, advanced technology platforms, as well as a professional technical team, Creative Biolabs has been a world-leading CRO in the field of ribosome research serving clients from more than 50 countries and districts. The custom service portfolio covers all aspects of the ribosome field from ribosome isolation to omics analysis to meet clients’ unique needs. Featured services include ribosome separation and extraction, ribosomal analysis, and ribosomal marker antibody development.
(YorkPedia Editorial):- New York City, New York Jan 18, 2023 (Issuewire.com) – Ribosomes, the site of protein synthesis in the cell, are vital for cell growth and survival. In the last few decades, a number of diseases have been discovered to be related to ribosomes. Understanding their great potential in the research on disease treatment, Creative Biolabs has unveiled a series of CRO services, highlighting ribosome analysis services.
With industry-leading expertise in ribosome research, Creative Biolabs has established a complete experimental platform for ribosome purification and analysis. The custom analysis services cover ribosomal transcriptome and ribosomal proteomics.
The scientist team believes that to understand ribosome translation and regulation, it is essential to determine the location and number of ribosomes on mRNA in vivo, thus is dedicated to assembling a one-stop ribosomal transcriptome analysis service, including but not limited to
- Ribosome Profiling: Preparation of physiological samples, nuclease digestion to remove unbound fragments, ribosome-protected fragment purification, library construction, deep sequencing, and computational analysis.
- Polysome Profiling: Preparation of cell lysates and sucrose gradients, isolation of polysomes, RNA isolation and RT-qPCR MQ, protein isolation, and SDS-PAGE.
- Ribosome Complex Profiling: Global translation initiation sequencing (GTI-Seq) technology to cover the whole profiling process.
- Ribosome RNA Sequencing: Digest free mRNA with nucleases, and enrich them for ribosome-mRNA complexes to obtain the target RNA fragment, library construction, and data analysis.
Considering ribosomal proteomics a powerful tool to understand the translation mechanism of ribosomes, Creative Biolabs now provides customized ribosomal proteomics services based on the standard process.
- Ribosomal Proteome Identification: Label-dependent strategies (SILAC, iTRAQ, ICAT, etc.) and label-independent strategies (coupling RFHR 2-DE with MALDI-TOF MS and MRM).
- Ribosomal Protein Expression and Analysis: Plasmid construction, gene expression, protein purification, protein expression, ribosome-interacting proteins analysis, etc.
The expert team ensures a vast variety of data and initiatives around clients’ ribosome solutions, covering translational control and measure gene expression, translation start sites, the rate of protein synthesis, and the prediction of protein abundance, which will help clients make informed decisions and set the right groundwork to succeed.
Detailed information can be found at the official website https://ribosome.creative-biolabs.com/.
About Creative Biolabs
Equipped with cutting-edge instruments, advanced technology platforms, as well as a professional technical team, Creative Biolabs has been a world-leading CRO in the field of ribosome research serving clients from more than 50 countries and districts. The custom service portfolio covers all aspects of the ribosome field from ribosome isolation to omics analysis to meet clients’ unique needs. Featured services include ribosome separation and extraction, ribosomal analysis, and ribosomal marker antibody development.
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